Joan brugge boston

We have carried out siRNA screens to identify genes that inhibit or enhance cell migration and invasion and are investigating the mechanisms responsible for these events and establishing whether these pathways are involved in invasion in vivo.

A major focus is on proteins that regulate cell-cell adhesion and collective migration. We are also investigating pathways that regulate tumor metastasis.

Other studies involve investigations of cellular pathways that control normal differentiation of breast epithelial cells in order to understand the contribution of factors and pathways that regulate these events in tumorigenesis. Websites Lab Website. Community or Program Affiliation Cell Biology. Developmental and Regenerative Biology.

Discipline Biochemistry. Akt regulation of glycolysis mediates bioenergetic stability in epithelial cells. Elife Nano Lett Systems analysis of apoptotic priming in ovarian cancer identifies vulnerabilities and predictors of drug response. Metabolic changes promote rejection of oncogenic cells.

Nat Cell Biol ; Clin Cancer Res Starved epithelial cells uptake extracellular matrix for survival. Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo.

NPJ Breast Cancer ; Cancer Res ; Mutant p53 regulates ovarian cancer transformed phenotypes through autocrine matrix deposition. JCI Insight Cell Metab ; Cytokinesis involves a nontranscriptional function of the Hippo pathway effector YAP. Sci Signal ; 9:ra Sci Rep ; Cancer: The enemy of my enemy is my friend. Nature ; Signal transduction in cancer. Cold Spring Harb Perspect Med Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours.

Live free or die: cell-cell adhesion regulates sensitivity to trail-induced apoptosis. Dev Cell ; Oncogene-like induction of cellular invasion from centrosome amplification. Nature Mesenchymal gene program-expressing ovarian cancer spheroids exhibit enhanced mesothelial clearance.

J Clin Invest Mapping the dynamics of force transduction at cell-cell junctions of epithelial clusters. Elife ; 3:e Chaperone-mediated autophagy degrades mutant p Genes Dev ; PDEF promotes luminal differentiation and acts as a survival factor for ER-positive breast cancer cells. Evidence for a multipotent mammary progenitor with pregnancy-specific activity.

Breast Cancer Res ; R Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion.

Substrate stiffness regulates cadherin-dependent collective migration through myosin-II contractility. J Cell Biol ; February Congratulations to Natalie Hendrick for a successful thesis defense! Also big thumbs up to Isaac Harris for his new paper in Cell Metabolism on glutathione depletion in cancer.

Also congratulations to Claudia Iavarone on her paper published in Molecular Cancer Therapeutics , studying combination treatment of high-grade serous ovarian cancer! Big thanks to captain Natalie Hendrick for leading the team!

September Congratulations to Yannis Zervantonakis for soon starting his own lab in University of Pittsburg! Check out his lab website and contact him for lab positions. Email Nobu if you are interested in applying to his lab.

Jenn is starting her Ph. June The lab bid a bitter-sweet farewell to Jon Coloff before he moves to University of Illinois at Chicago to start his own lab. Good luck Jon! Check out Jon's lab website if you are interested in joining.

Johan gave a great short-talk presentation at the Mammary Gland Biology Gordon Research Seminar on intratumoral heterogeneity. Here is Harvard's press release. Big thanks to Natalie and Rosa for organizing the gathering! Our Jennifer Rosenbluth gave a great presentation on mammary organoids.